http://www.nj.com/sports/index.ssf/2013/04/nfl_alumni_association_to_invi.html
Drug which could reverse depression symptoms draws interest of NFL Alumni Association
Craig Wolff/The Star-Ledger
on April 24, 2013 at 9:47 AM
The NFL Alumni Association announced today that it has invited thousands of former players to take part in a test for a powerful new drug which holds the promise of reversing major depression symptoms and even regenerating damaged parts of the brain.
Amid a class action lawsuit over the effects of years of heavy hitting on the football field, the old-timers say they are now looking for answers not just from lawyers but from scientists. They are also mindful that a number of former players in the throes of depression have committed suicide, careful to avoid shooting themselves in the head, and that their families have donated their brains for research. These tests then, they said, present a chance for former players to assist the research while they are still alive.
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“This has the potential of not just helping players, but also everyone suffering from major depression.
The drug, known as NSI-189, was created by Neuralstem, a Maryland research company. The drug, still in early clinical trials, the researchers say, do something typical antidepressants do not — regenerate parts of the brain that have suffered damage and even atrophied. It can, they say, not only reverse depression symptoms but also the loss of cognitive abilities.
Richard Garr, the company’s president, said he hopes that former players will enlist for what are known as Phase 2 trials.
“Most antidepressants,” Garr said, “work on the balance of chemicals in the head.”
The new drug, he said, reverses the course of atrophy that may have been caused by trauma and injury.