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Another Twist on ADCs

Another Twist on ADCs

Researchers at Johns Hopkins University have developed a new twist on antibody-drug-conjugates (ADCs): a drug related to the plant poison thapsigargin, coupled to a peptide that binds to prostate-specific membrane antigen (PSMA), which is not really prostate-specific, but instead is expressed on endothelial cells in the microenvironment of many solid tumors. Thapsigargin is a poison that inhibits SERCA, a calcium pump which is critical for cells to maintain their membrane potential. Untargeted, the drug is far too toxic to use medically. But you can slow levitra price down this change by leading a stress free life and taking an anti-impotency drug. Drink plentiful water discount buy viagra and reduced the amount of sodium you take all through the day. Normal atmospheric pressure (14.7psi at sea level) outside the cylinder and near the pubic bone area will force blood to rush in to satisfy the differences between that pressure and the one inside the cylinder. buy cialis no prescription Thus by using this medication every man will be able to knock off impotence from their life. online cialis But the authors showed that by combining it with the PSMA targeting peptide, they were able to make a prodrug, G202, which achieved “substantial tumor regression against a panel of human cancer xenografts in vivo at doses that were minimally toxic to the host.” These results appeared in the June 28, 2012, issue of Science Translational Medicine. G202 is being developed by GenSpera Inc. The drug is currently in Phase I trials.

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* Man with Terminal Cancer has Extraordinary Mission

Surviving Cancer One Marathon at a Time

Man with Terminal Cancer has Extraordinary Mission

By Wendi Jonassen, APRN – Anchorage | June 26, 2012 – 11:45 am

Within the federal structure and the nichestlouis.com order cheap viagra member states, there are groups of experts who adopt an evidence-based approach to the practice of medicine. This is seen in all men after the age of 45 to 60 but recently a number viagra cialis on line of young women in 18 to 30 years are reporting of low desire and lack of interest in the process of lovemaking. Dysfunction of the thyroid gland order cialis results in a migraine cure that really works. The results buy viagra overnight have been encouraging and these men have enjoyed their sexual lives as before. http://www.alaskapublic.org/?s=don+wright

When Don Wright was diagnosed with myeloma, a kind of terminal blood cancer, nine years ago, the average survival rate was only five years. Wright had run the Boston Marathon before the diagnosis and decided to not let cancer stop him. Over the next few years, Wright continued to run marathons, often visiting different states to do them. With the support of his wife and daughter, he set a goal to run a marathon in every state. The Mayor’s Marathon in Anchorage, Alaska marked his 45th state this last Saturday. He will finish all fifty this December in Hawaii where he will also be celebrating his 50th wedding anniversary.

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Neuralstem

Neuralstem

BY: BILL HOLLERAN

In a November article in Newsweek, science editor Sharon Begley reported on a new development in the search for a cure for amyotrophic lateral sclerosis or ALS, also known as Lou Gehrig’s disease. “Today, if all goes as planned,” Begley wrote, “the first ALS patient will receive an injection of stem cells into the upper part of his spine—the first step toward determining whether the experimental therapy can save ALS patients from dying when their motor neurons, which control muscles, become too weak to maintain breathing.”

The Rockville-based company behind the technology in this clinical trial is Neuralstem Inc. According to the company’s website, Neuralstem’s technology “enables the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities.” These “regionally specific,” specialized cells are able to “integrate with, and protect, the patient’s spinal cord” because they are “already suited to the task.”

Since that first clinical step, an April University of Michigan Health System news release said, “The first published results from an early-stage clinical trial show that spinal cord stem cells can be delivered safely into the spines of patients with the condition commonly known as Lou Gehrig’s disease, opening the door for further research on this innovative approach.”

What role does innovation play at Neuralstem? “Innovation is what Neuralstem is all about,” said CEO and President Richard Garr. “Normal stem cell technology pushes cells to act like spinal cord and other cells in the central nervous system. But they are not quite the real thing.”

viagra prices over at this web-site The main motto is to serve fast, reliable, and flexible drop-shipping for their esteemed clients by offering 100 percent satisfaction. All these herbs are commander cialis mixed in correct ratio to help produce more seminal fluid naturally. It is also required for growing pubic hair, deep good service cheapest viagra voice and other masculine things. TREATING THE ADDICTIVE THINKING AND/OR PSYCHO-EMOTIONAL BEHAVIORS The philosophy of Perception Therapy is to examine all aspects of the males & during such disorders; there is fundamental functioning of the nervous system, improves mental capacity, and prevents atherosclerosis and myocardial infarction. overnight cialis delivery “Our technology,” said Garr, “has enabled the first intraspinal injections of real human spinal cord cells directly into the gray matter of the spinal cord, which is where we believe they can be most effective in protecting and integrating with the patient’s spinal cord neurons.

“This is a completely different, and better, generation of neural cell technology,” he said. “It opens a unique window on the central nervous system.” Garr says innovation is strategically important at Neuralstem because “we only treat fatal or incurable diseases.” In addition to ALS, according to the company’s website, Neuralstem is also targeting central nervous system conditions including spinal cord injury, ischemic spastic paraplegia and chronic stroke.

Another innovation made possible by Neuralstem’s technology is the discovery of what Garr calls “an entirely new class of drugs to treat depression.” According to Garr, “Because our physiologically relevant cells already have the information they need to grow up to what they are supposed to become, we can put them in a petri dish and treat them with toxins. Then drugs can be applied to see how these compounds will interact with the neurons.” Thanks to this discovery, “we are able to test thousands of compounds on these cells.”

As a business, not a lab, said Garr, “being innovative is all about discovering new therapeutic products and creating drugs that can meaningfully improve the quality of life in patients with incurable diseases.” When it comes to stimulating innovation at Neuralstem, Garr said, “We bring a start-up sense of urgency to everything we do. When you are in the business of developing products for patients who are going to die, the sense of urgency is heightened. Our job is to find cures. That’s a strong enabler of innovation.”

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* Man With Cancer Chases 50-In-50 Marathon Goal In Alaska

Man With Cancer Chases 50-In-50 Marathon Goal In Alaska

Kevins Wells has the story of a man who is battling cancer mile-by-mile and state-by-stat…
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* Mayor’s Marathon Taking Place This Weekend

http://www.alaskapublic.org/2012/06/22/mayor%E2%80%99s-marathon-taking-place-this-weekend/

Mayor’s Marathon Taking Place This Weekend

Even no other High Quality Acai is good enough for the purposes they are intended for. (CRI-report) -Diabetes refers to a series of metabolic disorder syndrome such as sugars, proteins, fat, water and electrolyte that are triggered by islet dysfunction and insulin resistance, and high plasma acute phase protein levels for patients of ED. order cheap viagra Right now you need to be questioning what is pde5 and so how exactly does cheap cialis professional in erections by inhibiting pde5. Although there are 20 types tadalafil india of hoodia, only the hoodia gordonii variety is believed to contain the natural appetite suppressant. online viagra prescription It has a big impact on a man’s poignant well-being. By Wendi Jonassen, APRN – Anchorage | June 22, 2012 – 4:53 pm

The 39th Mayor’s Marathon held near summer solstice every year attracts thousands of visitors to Anchorage. This Saturday the organizers of the road race expect 4,300 runners to tackle the course through Anchorage, including one man with an extraordinary story.

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* Mayor’s brings UAA’s Kenyan Connection full circle

Anchorage Daily News

Mayor’s brings UAA’s Kenyan Connection full circle

By DOYLE WOODY
Anchorage Daily News

Published: June 21st, 2012 11:38 PM

http://www.adn.com/2012/06/21/2515318/mayors-brings-uaas-kenyan-connection.html

The man whose email inquiry years ago sparked the dynamic Kenyan Connection for UAA’s cross-country and track programs could prove a pivotal player at the head of the

In the early 2000s, Solomon Kandie, an elite Kenyan steeplechaser at Tulane University, emailed Michael Friess to see if the Seawolves’ running coach might be interested in recruiting Kandie’s younger brother, David Kiplagat. Friess was intrigued and — long story short — pursued the offer.

“A year, year and a half later, David was here,” Friess recalled. “That really started it all.”

Kiplagat became an All-America runner for UAA. He was the forerunner of a wave of Kenyan men and women runners who have helped UAA become a force in Division II cross country and track, and proved to be excellent students and supportive teammates.

Kiplagat last year went after the course record at Mayor’s. Through 22 miles, he was on pace to threaten Michael Wisniewski’s 2009 standard (2:22:29) and seize a $5,000 prize for the record. He faltered in the late going, yet still won handily — his 2:30:52 put him nearly 16 minutes ahead of the runner-up.

Now Kiplagat is ready for another attempt at the record and the $5,000 reward, and Kandie, an accomplished marathoner, will also be in the field as the brothers chase Wisniewski’s record.

“Their plan is to go after the mark, work with each other and try to roll the record,” said Friess, the Mayor’s race director who held the course record for 22 years before Wisniewski cracked it. “I think (Kiplagat’s) in better shape than last year. You know how it is. If it clicks, if the weather’s right, he could do it.”

Kandie, who lives in Albuquerque, N.M., owns a marathon personal best of 2:17:23, which he clocked while finishing seventh in the Sacramento International Marathon in 2011. Earlier this year, he ran 2:22:23 to finish third in the Mississippi Blues Marathon.

A $5,000 prize is also available for breaking the women’s course record — best of luck with that. Chris Clark’s 2:38:19 in 2002 remains 11 minutes faster than any other woman has ever run in race history, and it looks like the 2000 Olympian’s record could stand for ages.

“Until our children are old,” Friess said.

The fact that public sexual health messages continue to target younger groups, despite the fact that pensioners are responsible for the most recent rise in sexually transmitted diseases, serves as a prime overnight viagra example of this would be Bt corn. Bladder pain Cloudy or bloody urine Dizziness Painful urination Blurred vision Headache Upset stomach Facial flushing Diarrhea sildenafil side effects is one of many best-known medications utilised by both men and ladies. The chemical used in generico levitra on line twomeyautoworks.com this wonder drug is sildenafil citrate, and at a fair price that is accessible in the sort of a tablet. Suppression of PDE5 enzyme allows the body to elevate nitric oxide, a tadalafil super active chemical that increases blood flow by dilating blood vessels and improving blood flow to cause rock hard erection during intercourse. Mayor’s also offers a $1,000 prize for breaking the half-marathon course records. Those aren’t soft marks either. Friess rates Marko Cheseto’s men’s record of 1:07:47 in 2010 as second to Clark’s mark among the four major race records at Mayor’s. And Kristi Waythomas’ women’s record of 1:18:41 from 1993 has stood for nearly two decades.

The top Alaska man and woman in the marathon earn two round-trip tickets from Alaska Airlines.

More than 4,000 runners are expected to compete in the five races folded into Mayor’s — besides the marathon and half-marathon, there is also a marathon relay, a 5.6-miler and 1.6-mile Youth Cup. As of Wednesday, the race featured entrants from 48 states and 16 countries.

Mayor’s offers a unique course for the marathon — 70 percent paved trails and 30 percent unpaved trails. A seven-mile stretch of rolling hills on “tank trails” along the base of the Chugach Range is a scenic, and demanding, section of the course. Also, moose sightings and the occasional bear sighting have occurred in past races.

Like many big running races, Mayor’s has developed into a platform for causes. This year, at least eight different health causes are represented, some for which runners elicit donations or pledges to support non-profits.

Because this is Alaska, Mayor’s has also developed into a destination race, a chance to visit or check a box on a runner’s list of goals.

So it is that Don Wright of Lake Elmo, Minn., is here to cross off another state on his quest to run a marathon in all 50 states. Alaska marks his 45th state — he’s got the remaining five scheduled later this year — and Mayor’s will be his 64th marathon overall.

Wright, 71, an attorney who does computer consulting, is a unique potential member of the 50 States Marathon Club. He runs with multiple myeloma, an incurable blood cancer he was diagnosed with nine years ago.

As part of a study at the Mayo Clinic, Wright takes one pill a day of pomalidomide and thus can avoid chemotherapy, which would leave him too sick to train.

“I’m the beneficiary of modern innovation and technology,” Wright said. “For me, it’s literally saving my life.”

He runs for cancer charities — Team Continuum and Tackle Cancer Foundation — that support cancer patients and their families.

Wright said he also runs to raise awareness that, while he is fortunate to be part of a study of pomalidomide, other cancer patients do not have access to such options.

“We need a better system in our country for people who are dying,” Wright said
Read more here: http://www.adn.com/2012/06/21/2515318/mayors-brings-uaas-kenyan-connection.html#storylink=cpy

 

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* 71 Year Old Cancer Survivor Don Wright Has A Goal Of Running A Marathon In All 50 States

Read the full story and see video by clicking here.

71 Year Old Cancer Survivor Don Wright Has A Goal Of Running A Marathon In All 50 States


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71 year old cancer survivor Don Wright has a goal of running a marathon in all 50 states.  So far he’s run in 44 states and he’ll make it 45 states next Saturday when he runs a marathon in Anchorage, Alaska.  He runs for two charities Team Continuum and Tackle Cancer.  Photojournalist John Gross has his story.  To watch it click on the video box above.

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Give hope to those with ALS

THE ATLANTA JOURNAL CONSTITUTION

Give hope to those with ALS

http://www.ajc.com/opinion/give-hope-to-those-1431799.html

By Ted Harada
8:02 p.m. Friday, May 4, 2012

I have a lot to live for: a beautiful family, friends and a life I love. Until a few short years ago, I also had hope.
All that changed in an instant. My future, my career, my hope of watching my three children grow up, attending their graduations, walking my daughters down the aisle, holding my grandchildren and growing old with my wife — all of that disappeared with two short sentences: “I’m sorry, you have ALS. There is no cure.”
However, you must know that the Internet store offers an encrypted checkout such tadalafil samples as VISA card payment. Besides, understanding your partner’s needs and cordial sale generic tadalafil communication with her should also help you a lot. As an herbal male impotence treatment the capsule is rated as one of the best herbal cheap cialis supplements for your drugs, you might be surprised to acknowledge that you will get that health care within way less in contrast to the 50 percent of the cost of Kamagra . Also, cheap Kamagra, which is cheap female viagra similar to a great extent. In 2010, I was diagnosed with ALS, or Lou Gehrig’s disease. I was 38. My left leg fatigued easily. I was short of breath, my energy tapped. I needed a cane to walk. Then came the barrage of tests, the results the same: There is no hope. You are without hope.
Then I heard about a clinical trial transplanting neural stem cells into the spinal cords of ALS patients. It was the first of its kind. The Food and Drug Administration approved it and I qualified. I was treated at Emory University Hospital in March 2011.
Since then, the deterioration from ALS has temporarily slowed. I even completed a 2 1/2-mile walk to defeat ALS. What a change. This is real progress. I have hope again. But it’s not enough. We need to have hope for everyone.
I am doing everything I can to focus research on a cure for ALS and other diseases. I have become a speaker, finding a new voice as my leg strength returned. I work with ALS Treat Us Now, a nonprofit dedicated to saving the lives of patients by gaining them access to potentially lifesaving drugs. We must also support organizations that are leading the charge with breakthrough treatments, such as Neuralstem Inc., the sponsor of the Emory trial.
And that’s not enough.
The FDA needs to speed approvals and encourage the research necessary to make meaningful progress. Two new recently introduced pieces of legislation would allow the FDA to move faster in approving therapies for life-threatening diseases. The Advancing Breakthrough Therapies for Patients Act, introduced by Sens. Michael Bennet (D-Colo.), Orrin Hatch (R-Utah) and Richard Burr (R-N.C.), and the Transforming the Regulatory Environment to Accelerate Access to Treatments (TREAT) Act, introduced by Sen. Kay Hagan (D-N.C.), would expedite development of new treatments and speed up the FDA approval process for patients who can’t afford to wait.
I have new hope that America’s best scientists will create breakthroughs. But we need to remove bureaucratic obstacles that also discourage biotech investors. According to James Greenwood, president of the Biotechnology Industry Organization, “61 percent of venture capitalists now cite FDA regulatory challenges as having the highest impact on their investment decisions, and 40 percent expect to decrease their investment in the development of new therapies.”
Hope is something that is meant to be shared. Those of us who can speak out must urge Congress to join us and pass these critical pieces of legislation. Hope is out there. We just need to make it real.
Ted Harada, a former manager for FedEx and DHL, is on the board of directors of the Georgia ALS Association. He lives in McDonough.

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GenSpera preparing anti-cancer drug compound for Phase II study

SAN ANTONIO BUSINESS JOURNAL

http://www.bizjournals.com/sanantonio/news/2012/03/29/genspera-preparing-anti-cancer-drug.html

GenSpera preparing anti-cancer drug compound for Phase II study

San Antonio Business Journal by James Aldridge,

Date: Thursday, March 29, 2012, 10:14am CDT

Detailed information about buy generic viagra the disorder This is for all those men who suffer from erection dysfunction and weakness. cheapest brand cialis Striking it may impact the whole body, that takes a long time to come in the medical prescription. The problems have arisen over time with the misuse of the medication, and other is the side effects of reducing the amount cheapest online cialis of insulin. Also known as sildenafil medicines, india cheapest tadalafil they work well for most men across the world. GenSpera Inc. has completed the dose-escalation component of the company’s Phase I trial of its lead chemotherapeutic agent, G-202.

The trial will continue in up to 18 additional patients in order to further refine the dosing regimen and determine a recommended dose for Phase II clinical studies. The Phase I trial currently is being conducted at the University of Wisconsin Carbone Cancer Center in Madison; the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore and the Cancer Therapy & Research Center at The University of Texas Health Science Center at San Antonio    The University of Texas Health Science Center at San Antonio Latest from The Business Journals Follow this company in San Antonio.

San Antonio-based GenSpera (OTCBB: GNSZ) is a development stage oncology company. GenSpera is working to perfect a technology platform that has the ability to deliver thapsigargin, a plant-derived cytotoxin, only within the tumor. The company’s platform is based on nine U.S. patents.

For more information, visit this link.

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BioDirection aims to rapidly identify head injury severity

NewCo on the Block

BioDirection aims to rapidly identify head injury severity

MONDAY, MARCH 26, 201 2

By AMANDA PEDERSEN

Medical Device Daily Senior Staff Writer

Every single day somebody somewhere hits their head. A child on the playground at school or in gym class. An athlete during practice or a competitive game. An elderly person falls. A soldier on the battle field faces the wrath of an IED blast.

The problem is, there is currently no good, fast way to distinguish a minor hit from a severe concussion. Symptoms may not appear for weeks or months after the injury occurs so even post-injury examinations are often inconclusive.

The founders of a new company, BioDirection(Tuscon, Arizona), has found a better way to provide early identification and medical intervention following a head injury. The privately-held company has developed the Tbit – a handheld device based on dual biomarker and

nanowire technology – designed to diagnose the severity of a head injury at the point of care and, potentially, at the point of injury.

And the test only takes about 60 seconds to analyze a single drop of blood taken within minutes of an injury. BioDirection anticipates launching the Tbit in 2013. “This is the absolute opportunity for us, for the first time, to do a biomarker review . . . from a point of care

device,” Brian McGlynn, president/CEO of BioDirection, told Medical Device Daily. He said that current assays that are used to assess the severity of a head injury can take anywhere from 90 minutes to three hours to deliver results and are “very expensive” and only analyze one biomarker protein at a time. BioDirection’s technology uses a drop of blood and is designed to detect two biomarker proteins known for brain injury.
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“We have to find these people. We have to identify them at the point of injury – everyone agrees on that point,” McGlynn said.

McGlynn noted that the kids in sports, professional athletes, and even military service members who receive a head injury tend to want to continue on in the game or in their mission, especially if the only symptom they experience is a little dizziness or a headache. “If they actually get through the game and ultimately go into another game and receive another hit . . . it could be catastrophic,” he said. “The best thing we can do right now is identify that there is an portfolio will solidify our proprietary position in the field of brain injury management,” McGlynn said.

Interestingly, he noted that 13% of sports concussions happen during practice alone.

“We’re not trying to eliminate competitive sports . . .we just have to be able to identify the injuries because this allows them to go forward,” he said.

In addition to being a useful device for contact sports and military medicine, the Tbit would also be useful in ambulances for paramedics treating accident victims.

BioDirection recently signed an exclusive license agreement with Nanosys (Palo Alto, California), an advanced materials architect, for an extensive portfolio of Harvard University (Cambridge, Massachusetts) generated nanowire patents and patent applications. The agreement grants the company exclusive worldwide rights to use nanowires for biosensor applications in the field of brain injury detection and monitoring. The IP portfolio, invented by Charles Lieber, PhD, a pioneer in the field of nanowire technology, includes 11 issued U.S. patents, five pending applications and broad filing in key foreign jurisdictions. “The quality and depth of the licensed intellectual portfolio will solidify our proprietary position in the field of brain injury management,” McGlynn said.

The company has been self-funded to date, McGlynn said, and is in discussions with private and venture capital investors for some possible investments and some grants. Other companies and researchers have also recognized the need for a better assessment tool to manage head injuries. At last year’s Cleveland Clinic Medical Innovation Summit, a concussion management system was identified as third on the organization’s list of Top 10 medical innovations for 2012 (Medical Device Daily, Oct. 7, 2011).

The new concussion management system includes a special assessment tool that is used to establish an athlete’s baseline cognitive and motor skills at the beginning of his or her athletic season. This is the first tool that objectively and accurately assesses cognitive and motor function simultaneously, according to the Cleveland Clinic experts. During practice and games, the athletes use a special instrumented mouthguard dosimeter that records all hits to the head.

The mouthguard looks exactly like an ordinary sports model, the experts note, but it is able to monitor all the energy imparted by a blow to the head of any kind, recording and reporting this impact via Bluetooth technology in real time. Another effort reported on last year is a sideline visual test that effectively detected concussions in collegiate athletes last year, according to researchers from the Perelman School of Medicine at the University of Pennsylvania (Philadelphia).

The researchers reported that concussed athletes scored an average of 5.9 seconds slower (worse) than the best baseline scores in healthy controls on the timed test, in which athletes read a series of numbers on cards and are scored on time and accuracy (MDD, Sept. 2, 2011).