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* Sioux Falls Marathon attracts runners of all ages

KSFY (ABC, Sioux Falls, SD)

Sioux Falls Marathon attracts runners of all ages

http://www.ksfy.com/story/19496437/sioux-falls-marathon-attracts-runners

Posted: Sep 09, 2012 5:35 PM EDT Updated: Sep 09, 2012 7:06 PM EDT

2,000 runners ran a marathon in Sioux Falls today, including Don Wright, 71. He’s running a marathon in each of the 50 states.

He’s a cancer survivor and since his diagnosis 9 years ago, he’s run 66 marathons since being told he had a rare form of blood cancer.

He’s run over 1,500 miles, but he says his biggest complaint in this more than 26 mile race is runner’s knee.

“It’s a goal that keeps me going and it’s important to me and it’s my way of sticking that cancer right in the eye,” Wright said.

Wright is planning to run in Hawaii in December.

He’s also running in Alaska and New Mexico.

He has a blood cancer that affects cells in the bone marrow and can damage bones.
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It cannot be cured but luckily he can avoid chemo by taking medication and he’s able to train for these marathons.

The Sioux Falls marathon takes dozens and dozens of volunteers to make this marathon happen.

Some runners who took part in the race today came from all over the United States and around the country.

Volunteers tell us they met runners from New York and even Sweden.

“When you can get people from all over the U.S. and other countries it’s definitely going to help and Sioux Falls is a prosperous city. It has shown that with the promotion they have been doing,” Dave Tuch said.

Along with the marathon and half marathon today, there was also the Miracle 5k which raises money for the Children’s Miracle Network at Sanford Children’s Hospital.

The money raised will help sick kids in our area.

Some streets were closed in Sioux Falls because of this marathon.

Downtown street like Phillips Avenue, along with parts of Western Avenue.

Even the on and off ramps of Interstate 229.

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* Goal: 50 states, 50 marathons

Goal: 50 states, 50 marathons

Cancer survivor checks off Vermont

8:50 AM, Jul 7, 2012
Written by JOHN A. FANTINO
Free Press Staff Writer

Don Wright of Minnesota will run in Sunday's Mad Marathon in Waitsfield.Diagnosed with an incurable blood cancer, Don Wright was told by doctors he had just a few years to live. That was nine years ago.

Since then, the 71-year-old from Lake Elmo, Minn., has run 63 marathons in 45 states, an impressive feat that he’s scheduled to continue Sunday when he runs the Mad Marathon in central Vermont.

“I’m not just surviving,” Wright said. “I’m thriving.”

Wright has multiple myeloma, a disease that attacks white blood cells and often comes with a death sentence.

“They said the average survival was five years,” Wright said. “You start getting your house in order pretty quick when you hear that.”

He also started cranking out training miles and marathon applications. For someone who started running when he was 61 simply to lose a few pounds, Wright soon completed his first marathon. Two weeks after being diagnosed with multiple myeloma, he qualified for the Boston Marathon.

Wright has been attempting to run a marathon in each of the 50 states, a mission he’s scheduled to complete this year.

The inspiring tour continues Sunday at the Mad Marathon, a 26-mile hilly trek through the Mad River Valley. The Mad Marathon, which debuted last year, starts and finishes in Waitsfield. The course snakes through rolling farmlands, quaint villages, dirt roads and covered bridges.

For Wright, each step of the race will represent success in his battle against cancer.

Opting not to undergo chemotherapy because it would make him too weak to train, Wright instead turned to the trial-drug pomalidomide several years ago.

“It’s just a pill,” Wright said. “I’d like to inspire the country to make available drugs like this for people who are dying. Accessibility to experimental drugs is important to me because it is saving me life.”

Wright, a lawyer, travels to many of the races with his wife Ardis and daughter Sarah, both of whom participate in half marathons while he runs the full marathons. They drive to many of the events, although they flew to Alaska last week to run a marathon.

What does Wright plan to do after running marathons in New Hampshire, New Mexico, West Virginia and Hawaii this year to complete the journey of 50 marathons in 50 states while fighting cancer?

“There’s a lot of Canada we haven’t explored yet,” he said.

To read the full article  click here…

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R&D Changes Foreseen After Supreme Court Obamacare Decision

R&D Changes Foreseen After Supreme Court Obamacare Decision

http://www.genengnews.com/keywordsandtools/print/3/27740/

Insight & Intelligence™ : Jul 5, 2012

Innovative drugs that offer clear superiority over existing products likely among beneficiaries of overhaul.

Alex Philippidis

By upholding President Barack Obama’s healthcare overhaul, the U.S. Supreme Court set the stage for several key changes to drug development, industry executives and observers agreed in interviews.

Craig A. Dionne, Ph.D., president and CEO of GenSpera, told GEN that biopharma startups won’t win the funding they need without showing investors solid results earlier in development. Those companies, he said, must offer investors clear evidence that their new drugs offer “clearly superior” efficacy than existing products, or else risk reduced reimbursement from government and private insurance programs under the Patient Protection and Affordable Care Act.

“We have to develop drugs that are very highly and clear differentiated in such a way that they can command premium pricing, and command reimbursement,” Dr. Dionne said. “In oncology, which is our world, that could be something as simple as no effect on the bone marrow, so you no longer need all those supportive cares and all those other expenses that come with a drug with that kind of side effect profile.”

“Companies won’t even get started unless they can start making that argument. And they’re not going to get continued funding unless they can make that argument for premium pricing in the future,” Dr. Dionne added.

Richard Garr, CEO of Neuralstem, told GEN the law will aid drug R&D through its extension of insurance to 32 million more people, and its prohibition on insurers rejecting patients for pre-existing conditions. The latter, he said, should help kickstart research and product development of genetic diagnostics, and for rare disease therapy developers like his company.
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“You can’t overstate the importance of this act with respect to the impact it will have on people saying, ‘If we think we have something that’s worth pursuing here on the science side, now we have a much higher comfort level on the business side also,” Garr said. “I would think you will see a flood of genomic companies and testing. I think people will be much more responsive than they ever had been to that, now that they don’t have to worry about their insurance being canceled because they know.”

The healthcare law incorporated the Biologics Price Competition and Innovation (BPCI) Act of 2009, which mandates creation of an abbreviated approval pathway for biological products shown to be biosimilar to or interchangeable with an FDA-licensed biological reference product.

Among companies interested in BPCI are Quintessence Biosciences, a developer of anti-cancer, protein-based therapeutics.

Laura E. Strong, Ph.D., Quintessence’s president and COO, told GEN BPCI’s 12-year data exclusivity period is especially welcome by her company, which envisions itself a reference drug developer for future biosimilars.

“One of the issues that’s really important when you think about investment in innovation in biotech and pharma is, What’s the return on investment going to be? Having a more certain marketplace is definitely an improvement,” Dr. Strong said.

Action on biosimilars, however, will have to await FDA approval of final guidances for implementing BPCI; the agency issued three draft guidances on February 9.

FDA isn’t the only Washington hurdle for biosimilars. Obama’s administration wants to shrink exclusivity to seven years, claiming it would save $4 billion over 10 years; Congressional committees have sided with industry. “Our expectation is that the administration would continue those efforts, and we believe that would be certainly problematic,” Todd Gillenwater, svp, public policy with the California Healthcare Institute, told GEN.

He said industry will also continue fighting the law’s Independent Payment Advisory Board focused on cutting Medicaid costs. Biopharma groups say quality of care would be sacrificed, adding the board of 15 unelected presidential appointees requires more oversight.

Industry is also waiting for the states to establish the law’s insurance exchanges. “States continue to feel a lot of budgetary pressure, and there are other factors that may contribute to them not being able to move forward as quickly as they’d like with implementation,” Christie Bloomquist, a partner in the Washington, D.C., office of Hogan Lovells, told GEN. One such factor surfaced in recent days, as officials in Iowa, Louisiana, Mississippi, South Carolina, Texas, and Wisconsin said they may join Florida, where Gov. Rick Scott said Sunday he would not permit Medicaid expansion. All seven states are led by Republicans.

While biopharmas chafe at some provisions, industry mostly favors the healthcare overhaul. But to see the biggest benefit, companies will have to balance their desire to grow their pipelines and advance drugs with the law’s likely reality that investors will limit already-scarce dollars to treatments showing the best results.

Posted on

Another Twist on ADCs

Another Twist on ADCs

Researchers at Johns Hopkins University have developed a new twist on antibody-drug-conjugates (ADCs): a drug related to the plant poison thapsigargin, coupled to a peptide that binds to prostate-specific membrane antigen (PSMA), which is not really prostate-specific, but instead is expressed on endothelial cells in the microenvironment of many solid tumors. Thapsigargin is a poison that inhibits SERCA, a calcium pump which is critical for cells to maintain their membrane potential. Untargeted, the drug is far too toxic to use medically. But you can slow levitra price down this change by leading a stress free life and taking an anti-impotency drug. Drink plentiful water discount buy viagra and reduced the amount of sodium you take all through the day. Normal atmospheric pressure (14.7psi at sea level) outside the cylinder and near the pubic bone area will force blood to rush in to satisfy the differences between that pressure and the one inside the cylinder. buy cialis no prescription Thus by using this medication every man will be able to knock off impotence from their life. online cialis But the authors showed that by combining it with the PSMA targeting peptide, they were able to make a prodrug, G202, which achieved “substantial tumor regression against a panel of human cancer xenografts in vivo at doses that were minimally toxic to the host.” These results appeared in the June 28, 2012, issue of Science Translational Medicine. G202 is being developed by GenSpera Inc. The drug is currently in Phase I trials.

See the reprint click here…

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* Man with Terminal Cancer has Extraordinary Mission

Surviving Cancer One Marathon at a Time

Man with Terminal Cancer has Extraordinary Mission

By Wendi Jonassen, APRN – Anchorage | June 26, 2012 – 11:45 am

Within the federal structure and the nichestlouis.com order cheap viagra member states, there are groups of experts who adopt an evidence-based approach to the practice of medicine. This is seen in all men after the age of 45 to 60 but recently a number viagra cialis on line of young women in 18 to 30 years are reporting of low desire and lack of interest in the process of lovemaking. Dysfunction of the thyroid gland order cialis results in a migraine cure that really works. The results buy viagra overnight have been encouraging and these men have enjoyed their sexual lives as before. http://www.alaskapublic.org/?s=don+wright

When Don Wright was diagnosed with myeloma, a kind of terminal blood cancer, nine years ago, the average survival rate was only five years. Wright had run the Boston Marathon before the diagnosis and decided to not let cancer stop him. Over the next few years, Wright continued to run marathons, often visiting different states to do them. With the support of his wife and daughter, he set a goal to run a marathon in every state. The Mayor’s Marathon in Anchorage, Alaska marked his 45th state this last Saturday. He will finish all fifty this December in Hawaii where he will also be celebrating his 50th wedding anniversary.

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* Man With Cancer Chases 50-In-50 Marathon Goal In Alaska

Man With Cancer Chases 50-In-50 Marathon Goal In Alaska

Kevins Wells has the story of a man who is battling cancer mile-by-mile and state-by-stat…
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Go to this link and click on the video. “Man with Cancer. . . .”

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* Mayor’s Marathon Taking Place This Weekend

http://www.alaskapublic.org/2012/06/22/mayor%E2%80%99s-marathon-taking-place-this-weekend/

Mayor’s Marathon Taking Place This Weekend

Even no other High Quality Acai is good enough for the purposes they are intended for. (CRI-report) -Diabetes refers to a series of metabolic disorder syndrome such as sugars, proteins, fat, water and electrolyte that are triggered by islet dysfunction and insulin resistance, and high plasma acute phase protein levels for patients of ED. order cheap viagra Right now you need to be questioning what is pde5 and so how exactly does cheap cialis professional in erections by inhibiting pde5. Although there are 20 types tadalafil india of hoodia, only the hoodia gordonii variety is believed to contain the natural appetite suppressant. online viagra prescription It has a big impact on a man’s poignant well-being. By Wendi Jonassen, APRN – Anchorage | June 22, 2012 – 4:53 pm

The 39th Mayor’s Marathon held near summer solstice every year attracts thousands of visitors to Anchorage. This Saturday the organizers of the road race expect 4,300 runners to tackle the course through Anchorage, including one man with an extraordinary story.

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* Mayor’s brings UAA’s Kenyan Connection full circle

Anchorage Daily News

Mayor’s brings UAA’s Kenyan Connection full circle

By DOYLE WOODY
Anchorage Daily News

Published: June 21st, 2012 11:38 PM

http://www.adn.com/2012/06/21/2515318/mayors-brings-uaas-kenyan-connection.html

The man whose email inquiry years ago sparked the dynamic Kenyan Connection for UAA’s cross-country and track programs could prove a pivotal player at the head of the

In the early 2000s, Solomon Kandie, an elite Kenyan steeplechaser at Tulane University, emailed Michael Friess to see if the Seawolves’ running coach might be interested in recruiting Kandie’s younger brother, David Kiplagat. Friess was intrigued and — long story short — pursued the offer.

“A year, year and a half later, David was here,” Friess recalled. “That really started it all.”

Kiplagat became an All-America runner for UAA. He was the forerunner of a wave of Kenyan men and women runners who have helped UAA become a force in Division II cross country and track, and proved to be excellent students and supportive teammates.

Kiplagat last year went after the course record at Mayor’s. Through 22 miles, he was on pace to threaten Michael Wisniewski’s 2009 standard (2:22:29) and seize a $5,000 prize for the record. He faltered in the late going, yet still won handily — his 2:30:52 put him nearly 16 minutes ahead of the runner-up.

Now Kiplagat is ready for another attempt at the record and the $5,000 reward, and Kandie, an accomplished marathoner, will also be in the field as the brothers chase Wisniewski’s record.

“Their plan is to go after the mark, work with each other and try to roll the record,” said Friess, the Mayor’s race director who held the course record for 22 years before Wisniewski cracked it. “I think (Kiplagat’s) in better shape than last year. You know how it is. If it clicks, if the weather’s right, he could do it.”

Kandie, who lives in Albuquerque, N.M., owns a marathon personal best of 2:17:23, which he clocked while finishing seventh in the Sacramento International Marathon in 2011. Earlier this year, he ran 2:22:23 to finish third in the Mississippi Blues Marathon.

A $5,000 prize is also available for breaking the women’s course record — best of luck with that. Chris Clark’s 2:38:19 in 2002 remains 11 minutes faster than any other woman has ever run in race history, and it looks like the 2000 Olympian’s record could stand for ages.

“Until our children are old,” Friess said.

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The top Alaska man and woman in the marathon earn two round-trip tickets from Alaska Airlines.

More than 4,000 runners are expected to compete in the five races folded into Mayor’s — besides the marathon and half-marathon, there is also a marathon relay, a 5.6-miler and 1.6-mile Youth Cup. As of Wednesday, the race featured entrants from 48 states and 16 countries.

Mayor’s offers a unique course for the marathon — 70 percent paved trails and 30 percent unpaved trails. A seven-mile stretch of rolling hills on “tank trails” along the base of the Chugach Range is a scenic, and demanding, section of the course. Also, moose sightings and the occasional bear sighting have occurred in past races.

Like many big running races, Mayor’s has developed into a platform for causes. This year, at least eight different health causes are represented, some for which runners elicit donations or pledges to support non-profits.

Because this is Alaska, Mayor’s has also developed into a destination race, a chance to visit or check a box on a runner’s list of goals.

So it is that Don Wright of Lake Elmo, Minn., is here to cross off another state on his quest to run a marathon in all 50 states. Alaska marks his 45th state — he’s got the remaining five scheduled later this year — and Mayor’s will be his 64th marathon overall.

Wright, 71, an attorney who does computer consulting, is a unique potential member of the 50 States Marathon Club. He runs with multiple myeloma, an incurable blood cancer he was diagnosed with nine years ago.

As part of a study at the Mayo Clinic, Wright takes one pill a day of pomalidomide and thus can avoid chemotherapy, which would leave him too sick to train.

“I’m the beneficiary of modern innovation and technology,” Wright said. “For me, it’s literally saving my life.”

He runs for cancer charities — Team Continuum and Tackle Cancer Foundation — that support cancer patients and their families.

Wright said he also runs to raise awareness that, while he is fortunate to be part of a study of pomalidomide, other cancer patients do not have access to such options.

“We need a better system in our country for people who are dying,” Wright said
Read more here: http://www.adn.com/2012/06/21/2515318/mayors-brings-uaas-kenyan-connection.html#storylink=cpy

 

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* 71 Year Old Cancer Survivor Don Wright Has A Goal Of Running A Marathon In All 50 States

Read the full story and see video by clicking here.

71 Year Old Cancer Survivor Don Wright Has A Goal Of Running A Marathon In All 50 States


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71 year old cancer survivor Don Wright has a goal of running a marathon in all 50 states.  So far he’s run in 44 states and he’ll make it 45 states next Saturday when he runs a marathon in Anchorage, Alaska.  He runs for two charities Team Continuum and Tackle Cancer.  Photojournalist John Gross has his story.  To watch it click on the video box above.

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GenSpera preparing anti-cancer drug compound for Phase II study

SAN ANTONIO BUSINESS JOURNAL

http://www.bizjournals.com/sanantonio/news/2012/03/29/genspera-preparing-anti-cancer-drug.html

GenSpera preparing anti-cancer drug compound for Phase II study

San Antonio Business Journal by James Aldridge,

Date: Thursday, March 29, 2012, 10:14am CDT

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The trial will continue in up to 18 additional patients in order to further refine the dosing regimen and determine a recommended dose for Phase II clinical studies. The Phase I trial currently is being conducted at the University of Wisconsin Carbone Cancer Center in Madison; the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore and the Cancer Therapy & Research Center at The University of Texas Health Science Center at San Antonio    The University of Texas Health Science Center at San Antonio Latest from The Business Journals Follow this company in San Antonio.

San Antonio-based GenSpera (OTCBB: GNSZ) is a development stage oncology company. GenSpera is working to perfect a technology platform that has the ability to deliver thapsigargin, a plant-derived cytotoxin, only within the tumor. The company’s platform is based on nine U.S. patents.

For more information, visit this link.