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* Running Against the Odds

http://bayweekly.com/articles/people/article/running-against-odds

One in a thousand on the B&A Trail Marathon

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Sunday, March 4, a thousand men and women lined up to run the Annapolis Striders’ B&A Trail Marathon. Among them, 71-year-old Minnesotan Don Wright stood poised to begin his 63rd marathon in 44 states.

Only six states stand between Wright and his goal to complete a marathon in all 50 states.

Wright is training, traveling around the country and completing several marathons every year, as he has been for the last eight years — while fighting multiple myeloma, an incurable blood cancer.

“When I got the disease, it wasn’t hurting me yet, so I was in denial,” Wright says. “I am still in denial, and I plan on staying in denial.”

Multiple myeloma is a cancer of plasma cells that attacks and destroys bone. There are about 100,000 patients with 20,000 new cases diagnosed each year in the U.S. Causes are unknown; however, certain professions involving exposure to nuclear radiation, pesticides and petrochemicals have a higher risk factor.

One State at a Time

Wright started running a decade ago to lose weight. He ran his first marathon about two years later, days before his diagnosis. He kept running, determined to qualify for the coveted Boston Marathon, a goal he achieved in the first race after his diagnosis, Minnesota’s Twin Cities Marathon. Next, Wright headed to Arizona for a downhill marathon in Tucson.

His marathon quest evolved one state at a time.

“We started to pick off other states, never expecting that we’d be able to do 50 states,” Wright says. “It takes time if you want to do a few marathons a year, and I didn’t know how much time I had.”

Eight years ago, Wright’s survival time was estimated at about five years.    He attributes his energy and his cancer’s stability to a pill he has taken every night for the last four years. It’s an investigational drug still in the trial stages.

“I’ve met people who are no longer with us because of this disease,” Wright says. “It’s a serious thing, but because of this drug, we’re going all over the country celebrating life and really having a wonderful time.”

We is Wright plus his wife and daughter, who travel with him to each race and run either alongside him or in an accompanying half-marathon.

Cancer isn’t slowing Wright down, but he has suffered from a sports hernia — an abdominal wall strain — since August. His usual schedule of running 30-plus miles each week has been reduced to long walks, often through his local mall in Lake Elmo, just east of Minneapolis-St. Paul, to stay out of the cold winter mornings.

To help heal, Wright has adopted a routine of 30 seconds of running followed by 90 seconds of walking throughout a race. At that pace, he can finish within the race cutoff time (six hours for the B&A Trail Marathon) while avoiding further injury.

On Sunday, Wright finished in 5:32:47. Time, however, matters less to him than the running itself.

“I like to imagine that I’m just floating, that there’s no effort to it at all,” Wright says. “I’m just kind of drifting across the landscape, watching the houses and the trees and the other people go by. That’s one of my favorite things.”

Wright attributes his active lifestyle in helping hold off the cancer. His next marathon is in June in Alaska, followed by races in Vermont, New Hampshire, West Virginia, New Mexico and, in December, Hawaii. That’s 50.

“I think about the people I know who can’t do this,” Wright says, “and how lucky I am to be able to do it.”

Wright’s running raises money for two charities, Team Continuum (www.teamcontinuum.com) and Tackle Cancer (http://tacklecancerfoundation.org). Both help cancer patients and their families pay for living expenses.

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Scientists Transform Deadly Plant Into Cancer Killing Smart Bomb

Scientists Transform Deadly Plant Into Cancer Killing Smart Bomb

By Kristen Philipkoski
Feb 2, 2012 4:40 PM

The ancient Greeks called the thapsia garganica plant “deadly carrot,” because their camels would eat it and quickly die. The Roman emperor Nero mixed it with frankincense to treat bruises. Until the early 20th century it was used in a plaster to treat rheumatism—the side effects, however, were barely worth the cure.

But what happens when you deploy thaspia on a molecular level? You get a teeny tiny, very precise, cancer-killing grenade. It’s an entirely new approach that has its creators throwing around the word “cure.”

Thapsigargin, the active ingredient in the thapsia plant, does a fantastic job of killing tumor cells by destroying their calcium balance. But it will do that to any cell that crosses its path. So Genspera, a biotech company in San Antonio, Texas, found a way to strictly guide and control the drug through the bloodstream until it finds its target.

“That’s why we came up with the concept of producing a molecular grenade, so it activates only in the tumor,” said Craig Dionne, GenSpera’s president, CEO and director.

That’s no easy task. One of the reasons many cancer drugs cause such terrible side effects is because they leak into the bloodstream on their way to the tumor. The bone marrow is ravaged, hair falls out, and the liver and cardiovascular system can be damaged.

“We have none of that nonsense,” Dionne says.

The key to the cancer grenade’s precise explosive effect is its “pin,” a 5-amino-acid-long peptide that can be pulled only by an enzyme, called PSMA, found on the surface of blood vessels that feed cancer cells. Only when the peptide comes into contact with PMSA will it release the thapsigargin.
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Other chemotherapy drugs slow the growth of cancer, and doctors consider them a success if they prolong a patient’s life for just a few months.

“We’re not trying to slow the growth,” Dionne told me. “We’re dropping a neutron bomb in the neighborhood. Everything in the neighborhood dies and goes away.”

Traditional chemotherapy is also designed to kill fast-growing cells, i.e. cells that are dividing out of control like cancer tumor cells do. The problem is that cancer stem cells, which continuously give rise to new tumors, actually divide very slowly, which can lead to a relapse. In animal studies, Genspera’s drug killed all the cancer cells plus the stem cells, leaving nothing behind that could seed more cancer growth—hence the talk of a cure.

“It looks like what we’ve seen in animals will be replicated in humans—that’s what we expect to see,” Dionne said.

Not to get too overly optimistic: the drug is in the earliest phase of FDA clinical trials. So far, researchers are excited and hopeful because they’ve cranked up the dosage more than they ever thought possible, and still have not seen side-effects in patients. Twenty-six patients with various types of late-stage “solid tumor” cancer have participated in the trial and researchers will soon add 18 more. After that they hope to move on to the second phase of trials (FDA clinical trials usually include three phases: the first for safety, the second for safety and efficacy, and the final one to confirm safety and efficacy.)

Prostate cancer cells also grow slowly, so they can escape cancer treatments focused on killing fast-growing cells. Genspera’s next drug, which will be based on the same grenade technology, will target that disease. Also in the queue are brain and stomach cancer. Here’s hoping they bomb the crap out of all of them.

Image: Luigi Rignanese

http://gizmodo.com/5881640/scientists-transform-deadly-plant-into-cancer-killing-smart-bomb

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Scientists Use Spectroscopy to Study Black Holes, Stars, and Now Cervixes

Scientists Use Spectroscopy to Study Black Holes, Stars, and Now Cervixes

Scientists use spectroscopy to examine the make-up of celestial objects. Now, they’re taking the technology in a decidedly different direction and using it to detect cervical cancer.

Over the past decade, Guided Therapeutics has identified cellular markers specific to cervical cancer cells, which their new device identifies by shining a spectrum of light on the tissue. Like spectroscopy for planets and stars, the company’s LuViva Advanced Cervical Scan shines light on the object of interest, then analyzes how that light is reflected. The technique is non-invasive and doesn’t require tissue samples or lab tests, which is reason to celebrate for anyone who’s had a Pap-smear or cervical biopsy.

“Every molecule has a spectral fingerprint. If you hit it with a specific wavelength of light any tissue will reveal its nature and tell you something about itself,” Mark Faupel, CEO of Guided Therapeutics, told me during a phone interview. “We’ve adapted this technology used by NASA to identify whether there’s life on other planets to detect cancer cells in tissue in vivo (i.e. in a live person).”

In studies looking at 1,600 cervixes, the company’s scientists found that the device detected 90 percent of cervical cancers an average of two years earlier than Pap smears, the technique currently used by doctors for early diagnosis. Pap smears are a good way to detect cervical cancer early but they also lead to a lot of false positives—only 20 percent of patients who have abnormal Paps actually require treatment. That’s an 80 percent false positive rate. The test also completely misses two-thirds of pre-cancerous cells.

False positive or not, an abnormal Pap smear typically leads to a colposcopy, which is basically a quick but sometimes painful scrape of the cervix’s surface cells to obtain a biopsy.

Cervical cancer, which is usually caused by human papilloma virus, is a major killer of women, especially in developing countries where women have less access to Pap smears. In the United States where Pap smears are routine, most women catch pre-cancerous cells early enough that it’s 100 percent treatable by removing the abnormal cells with cryosurgery or laser therapy. But in places where Pap tests are not routine and cervical cancer often goes undetected until it has spread, LuViva could save lives. The device will be relatively inexpensive at about $20,000, so Faupel hopes smaller clinics will be able to afford one.

“We wanted to make it accessible to use on a reservation for Native Americans or rural clinics in developing countries,” he says. “This can be used for the underserved population, not just afforded by large industrial hospital complexes.”

The National Cancer Institute has granted Guided Therapeutics $6 million to develop the technology, and the company hopes to receive final FDA approval to market the device sometime this month.

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Scientists Use Spectroscopy to Study Black Holes, Stars, and Now Cervixes

Scientists use spectroscopy to examine the make-up of celestial objects. Now, they’re taking the technology in a decidedly different direction and using it to detect cervical cancer.

Over the past decade, Guided Therapeutics has identified cellular markers specific to cervical cancer cells, which their new device identifies by shining a spectrum of light on the tissue. Like spectroscopy for planets and stars, the company’s LuViva Advanced Cervical Scan shines light on the object of interest, then analyzes how that light is reflected. The technique is non-invasive and doesn’t require tissue samples or lab tests, which is reason to celebrate for anyone who’s had a Pap-smear or cervical biopsy.

“Every molecule has a spectral fingerprint. If you hit it with a specific wavelength of light any tissue will reveal its nature and tell you something about itself,” Mark Faupel, CEO of Guided Therapeutics, told me during a phone interview. “We’ve adapted this technology used by NASA to identify whether there’s life on other planets to detect cancer cells in tissue in vivo (i.e. in a live person).”

In studies looking at 1,600 cervixes, the company’s scientists found that the device detected 90 percent of cervical cancers an average of two years earlier than Pap smears, the technique currently used by doctors for early diagnosis. Pap smears are a good way to detect cervical cancer early but they also lead to a lot of false positives—only 20 percent of patients who have abnormal Paps actually require treatment. That’s an 80 percent false positive rate. The test also completely misses two-thirds of pre-cancerous cells.

False positive or not, an abnormal Pap smear typically leads to a colposcopy, which is basically a quick but sometimes painful scrape of the cervix’s surface cells to obtain a biopsy.

Cervical cancer, which is usually caused by human papilloma virus, is a major killer of women, especially in developing countries where women have less access to Pap smears. In the United States where Pap smears are routine, most women catch pre-cancerous cells early enough that it’s 100 percent treatable by removing the abnormal cells with cryosurgery or laser therapy. But in places where Pap tests are not routine and cervical cancer often goes undetected until it has spread, LuViva could save lives. The device will be relatively inexpensive at about $20,000, so Faupel hopes smaller clinics will be able to afford one.

“We wanted to make it accessible to use on a reservation for Native Americans or rural clinics in developing countries,” he says. “This can be used for the underserved population, not just afforded by large industrial hospital complexes.”

The National Cancer Institute has granted Guided Therapeutics $6 million to develop the technology, and the company hopes to receive final FDA approval to market the device sometime this month.

Posted on

* Solace in numbers

http://www.thestarnews.com/chula-vista/solace-in-numbers/

The Star-News

Solace in numbers

Sat, Jan 07 2012 12:00 PM Posted By: Allison K. Sampité

In October 2006, Guadalupe Moreno was taken to the emergency room for severe bone and kidney pain and a fever.  During the second day of her one-week stay at Scripps Hospital in Chula Vista, doctors told Moreno something that would change the rest of her life.

Moreno, now 64, was diagnosed with multiple myeloma, an incurable blood cancer where abnormal cells collect in the bone marrow and form tumors.

It’s the second most common blood cancer after lymphoma, affecting an estimated 750,000 people worldwide.

In July 2007, Moreno went to the University of California, San Diego, where she received a stem cell transplant.

“The transplant worked for 20 months — my cancer was in remission then it began slowly coming back and I started chemo again,” she said.

Moreno, like many people who are diagnosed with multiple myeloma, have never heard of the disease and think of it as melanoma, the leading cause of death from skin disease.

Years ago, multiple myeloma mostly affected men in their 60s and older, but today, diagnosis includes women and those younger than 30.

There are approximately 19,900 new cases of myeloma in the United States each year, according to the International Myeloma Foundation, which works to improve treatment options to improve the quality of life for patients.

Although multiple myeloma is treatable with medication, radiation and chemotherapy, the condition can cause bone pain, frequent infections, dizziness and fatigue.

Moreno takes steroids and two chemotherapy treatments in cycles, which helps minimize her pain, but causes side effects such as nausea.

While symptoms of multiple myeloma can be strong, they are not easy to detect at an early stage.

For some people like Elliot Recht, who was diagnosed during an annual physical 14 years ago, there are no symptoms at all.

Recht is one of two leaders for the San Diego Multiple Myeloma Support Group, but started off as a member when he was first diagnosed, taking over after group founder Fred Gloor passed away.

“I am very fortunate,” Recht said. “I’ve been pretty asymptomatic the whole time.”
Still, patients must manage their symptoms.

Because multiple myeloma affects plasma cells responsible for producing antibodies, it often affects the immune system, making patients more susceptible to infections, colds and viruses. It can also cause build-up of the M protein, which thickens the blood.
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Moreno explained the importance of washing her hands and dishes well and often to rid them of bacteria and how she can’t eat fruit or vegetables that grow underground because of pesticides.

When Recht was diagnosed, the life expectancy of patients was only three years, so he decided to stop working full time as a photographer.

“Why work so hard when you have such a short time to live?” he said.

Dr. Brian Durie, chairman of the foundation’s board, said that in the last decade, six new agents have been created to fight myeloma.

“Novel therapies are much better tolerated and work for a whole lot longer than chemotherapy does,” Durie said. “On average, life expectancy has doubled in the last decade from three to six years … allowing patients to return to a longer, fuller life.”

Chula Vista resident Lanorris Sewell was diagnosed at Scripps Hospital in Chula Vista in April after his back went out. Blood tests, a bone marrow biopsy and MRI confirmed he had multiple myeloma.

Sewell, 49, retired from the Navy in 2003 after 20 years working with chemicals to strip rust off airplanes. Prior to being diagnosed Sewell hadn’t heard of multiple myeloma.

“One thing I have learned about the cancer thing is that you have to stay positive if you want to beat it, otherwise you’re defeated,” he said.

Although the reason why people develop multiple myeloma is unknown, there are man-made risk contributors that include environmental pollution, stress and pesticides.

In Recht’s case, he grew up in Pittsburgh where he said he believes that air pollution, caused by the burning of coal and production of steel and iron, might have contributed to his condition, in addition to medal casting, oil paints, turpentine and clay.

“It’s a fine line between awareness and susceptibility,” Durie said. “Only a small percentage of those exposed have a genetic predisposition to it. People who do get myeloma aren’t able to break down these chemicals because they are slow metabolizers.”

Sewell and Moreno live on disability, unable to work, but attend support group meetings, which offer information on finances, give emotional support, and provide a better understanding of myeloma.

“It helps them realize that they are not alone in this battle and struggle,” Recht said.

“This is a type of cancer where education is the best possible thing.”

Moreno also attends meetings at Sharp Medical Center’s Leukemia and Lymphoma Society in Chula Vista.

“It’s good to learn and talk with other people that are like you and exchange your experiences,” she said. “I think when you have cancer, you have to fight to get well—you have to think positive.”

For information on support groups visit www.multiplemyelomasandiego.org.

Posted on

* A Miracle Drug Keeps This 70-Year-Old Cancer Patient Running Marathons

Don Still Going

http://gizmodo.com/5867859/a-miracle-drug-keeps-this-70+year+old-cance

Don Wright was diagnosed with myeloma—cancer in his blood cells and bone marrow—two weeks after running his first marathon. His doctor gave him a five-year survival estimate. Eight years later he has run 60 26.2-mile races in 41 states and takes just one pill per day to keep his cancer at bay.

“I feel wonderful,” Wright says. He and his family run the races together: his wife and daughter run half marathons while he does the whole shebang. His only complaint is a touch of runner’s knee every now and then.

Wright’s miracle drug is called pomalidomide, and it’s still in clinical trials. It’s one of several emerging therapies over the past decade that have doctors stunned and cautiously ecstatic about their effectiveness. Other drugs in this group include thalidomide (infamous for causing birth defects in the 60s) and lenalidomide, which are called immunomodulating agents. While not a cure, they could make treating cancer as relatively manageable as taking insulin for diabetes or a statin for high cholesterol.

Dr. Brian Durie, the co-founder and chairman of the International Myeloma Foundation, is amazed by Wright’s running stamina. “It’s mind boggling, for God’s sake. It’s amazing.”

The key, he says, is to stay on the treatment, just like taking insulin regularly to keep diabetes at bay. It’s a major and welcome shift from the comparatively shorter but heavy-hitting and damaging doses of chemotherapy and radiation that were the baseline treatments for myeloma 10 years ago. Most patients will take a lifetime of taking one pill per day over months of hair loss and severe nausea.

It helps in burning calories and improves the blood flow to the organ. levitra pills from canada slovak-republic.org for sale viagra In the majority of cases, the problem is due to erectile dysfunction. There are studies that show that cialis overnight far lesser side effects than its counterparts, lasts longer and is not proper. The increasing stress and improper diet causes discount generic cialis to produce some hormonal disorders in the body like diabetic problems. “These molecules are multifunctional,” Dr. Durie says. “They shut down pathways in the cancer cells and the micro-environment in the bone marrow.”

Nowadays, most newly-diagnosed patients try one of these novel drugs since they work so well for some people. The problem is, the treatments are unpredictable and work differently for everyone. That’s why Dr. Durie and his colleagues are taking samples of patients’ bone marrow and using genetic profiling to determine who will respond best to which drug.

First we sequence the whole genome, then we break it up into smaller sequences about 200 nucleotides long. Then you sequence those, and you end up with literally millions of these little pieces. You line those up and compare the malignant cells with the normal cells.

By comparing these super-detailed sequences of DNA, Durie hopes to one day determine who will respond best to each drug on the list of novel treatments for myeloma.

Meanwhile, Wright hopes to keep taking pomalidomide for as long as it keeps working for him. At 70, he’s beginning to slow down, but only slightly. His goal is to run a marathon in every state—he’ll rack up one more this weekend in Rehoboth Beach, Delaware. He has already won multiple marathons in his age group, his fastest race being 3:36. That’s twice as fast as my fastest marathon, which I ran when I was half Wright’s age. Clearly he loves running more than I ever did:

“I just cruise,” he says. “I coast.”

Posted on

* Human Factor: Running marathons while fighting cancer at 70

Click on the link below to view the video
http://www.cnn.com/video/#/video/health/2011/11/29/hf-don-wright-marathon.cnn
November 29, 2011

Human Factor: Running marathons while fighting cancer at 70

In the Human Factor, we profile survivors who have overcome the odds. Confronting a life obstacle – injury, illness or other hardship –- they tapped their inner strength and found resilience they didn’t know they possessed. This week we meet Don Wright, who developed a passion for running marathons later in life, right before getting diagnosed with cancer. His goal is to run 50 marathons in 50 states.

“I’ve made an appointment with an oncologist for you.” These are words that no one wants to hear from their doctor, ever. It was multiple myeloma, an incurable blood cancer with a median survival of about five years after diagnosis.

I had lost weight at Weight Watchers’, then started running, and had just run my first marathon. Myeloma attacks the bones, and a broken bone would stop my running, so I was determined to run the Boston Marathon before I lost the ability to do so. I qualified for Boston and then ran it, then a few more marathons here and there. I had no reasonable expectation of finishing all 50 states.

That was eight years ago. I’m now 70 years old and since the diagnosis I have run 60 marathons in 41 different states, including the Seattle Marathon last Sunday. After some treatments that didn’t stop it, the cancer has been stable for three and a half years on a novel investigational drug called pomalidomide, just a pill that I take once a day. I’m a beneficiary of modern innovation and research.

I have this incurable cancer, and my most pressing health problem is runners’ knee!
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My doctors are uniformly enthusiastic about the running as a way to strengthen my immune system and my bones. “We’re not sure why it works, but keep doing what you’re doing.”

We can’t know how long this treatment will continue to keep the cancer from growing, but for now, my family and I are relishing the extra time that I have been given, by traveling and doing these marathons together. They are a celebration of life!

I stand at the starting line and get choked up, thinking of the people I know who haven’t survived myeloma, and how lucky I am to be alive and able to run a marathon. I can’t wait to start the race. Even on a cold, rainy day in Seattle, I enjoyed every moment. As I run, I sometimes imagine that I’m just floating along, drifting past the scenery. I feel wonderful, and we’re going for all 50 states.

Since August I have also been running on behalf of Team Continuum, a charity started by a man with myeloma. It helps patients and their families meet their daily expenses while fighting cancer. Here’s how you can help:

– Click “like” on this Facebook page and a donor will contribute $5.00 at no cost to you: facebook.com/ERACECANCER.

– Go here if you would like to make your own donation directly to
TeamContinuum.net.

With my cancer I am very lucky to be able to run marathons, and I feel even more privileged to run them on behalf of other cancer patients.

Posted on

* Cancer patient runs marathons

Cancer patient runs marathons

Sanjay Gupta MD|Added on November 28, 2011

Dr. Sanjay Gupta talks to a cancer patient whose goal is to run a marathon in every state.
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* Running with, not from, cancer

http://www.startribune.com/local/east/132203933.html

Running with, not from, cancer

Article by: TIM HARLOW ,  Sunday, October 23, 2011

Don Wright, 70, plans to run a marathon in all 50 states, a goal he set eight years ago after he was diagnosed with an incurable form of cancer.

Don Wright, 70 didn’t begin running until he was 62, when he was diagnosed with multiple myeloma. Since then he has run 54 marathons in 36 states. Wright ran a practice run near his Lake Elmo home.

Marathon runners know that the 26.2-mile races provide plenty of opportunities for humbling moments. For Don Wright, the first occurs when the horn goes off and he crosses the starting line.

For Wright, 70, each race is another step in his battle to ward off multiple myeloma, a cancer that has no cure and often manifests itself through bone or back pain. It’s also an opportunity to raise money to help other cancer patients pay their medical bills.

“I get very emotional at the start, almost weepy,” said Wright, of Lake Elmo. “As I’m drifting past the scenery, I think about how fortunate I am and how I’m sticking my finger in the eye of the cancer.”

Since he was diagnosed with myeloma eight years ago, Wright has logged more than 1,400 miles in completing 57 marathons in 38 states. He’s won awards for first-place finishes in his age group and clocked times that allowed him to qualify for the prestigious Boston Marathon.

It’s always a thrill to cross the finish line, Wright said, but his proudest accomplishment has been making life better for others.

In each race — including the Marine Corps Marathon in Washington, D.C., on Oct. 30 and his second New York City Marathon on Nov. 6 — Wright runs for Team Continuum, a nonprofit that provides financial assistance to help cover daily living expenses for cancer victims and their families who are saddled with medical bills. Donations can be made at www.startribune.com/a721.

“Running for a great organization like Team Continuum is a way for me to help others lead better lives with cancer,” he said.

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Wright has already beaten those odds, and even though the cancer could sideline him any day, he jokes that his two most immediate concerns are runner’s knee and a sports hernia.

Wright has been able to keep myeloma’s ill effects at bay by skipping traditional chemotherapy and instead taking the experimental drug Pomalidomide daily. He makes monthly trips to the Mayo Clinic in Rochester for checkups. Running is his best form of physical therapy.

“The weight-bearing actually helps preserve bone density,” said Dr. Martha Lacy, Wright’s physician at Mayo who has studied the illness for more than 15 years. “He’s got lots of stamina and his attitude is amazing. He is focused on being well. He’s quite a guy.”

Although he ran cross country in high school, Wright only dabbled in running over the next few decades until he rediscovered his “runner’s urge” when he was in his early 60s, the age when myeloma is most likely to occur. He ran and completed his first marathon — Grandma’s in Duluth — in 4:30:11 in 2003. Just days later, he was diagnosed with the cancer.

“I was shocked. I had no symptoms,” said Wright, a former innovator at Maplewood’s 3M Co. “I thought ‘I have to hurry before it’s too late to run Boston.'”

He achieved that goal in 2004, clocking in at 4:16:07, which led to the larger goal of completing at least one marathon in all 50 states. He’s made it to 41 so far, cheered on by his biggest fans: his wife, Ardis, and daughter, Sarah, who run with him during most of his events.

Wright’s remarkable achievements — physically and medically — are giving doctors hope that one day there will be a cure for myeloma. While they still do not know what causes it, treatments such as Pomalidomide are allowing victims to live longer and maintain a higher quality of life, Lacy said.

“We have been impressed with the drug,” said Lacy, who noted that Wright is among 225 patients who are in a study group which allowed him to be put on the experimental drug. . “It doesn’t work for everybody, but there has been a high response,” Lacy said.

It’s not a cure-all, however, and symptoms could arise at any time. Wright said he has three hot spots in his bones and that makes him a bit nervous.

“There is just no way to know,” he said. “I have no intentions of letting that happen, but I’ve had a good life if that happens.”

Tim Harlow • 651-925-5039 • Twitter: @timstrib

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